The Midland Certified Reagent Company, Incorporated
The Company for Quality DNA & RNA Oligos
 
 
 
 
 
 
 
 
 
 

DNA and RNA Modifications
MIDLAND offers more than 100 DNA and RNA modifications. A modification is defined as any chemical entity covalently attached to synthetic DNA or RNA exclusive of the four major nucleotides present in each. Availability and price of many modifications are dependent upon supply of chemical materials and patent license agreements. Accordingly, certain modifications that have been described in the technical literature may not be available. However, over 100 modifications are routinely available. Please call or e-mail us for information concerning other modifications not listed below.

These are some of our most commonly requested modifications. To view the long list of modifications available from MIDLAND, click here. To contact us please click here.

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MODIFICATION PRICES
Synthesis Scale 50 nmole 200 nmole 1 µmole 10 µmole
At 3' end or 5' end
Biotin $45.00 $50.00 $90.00 $450.00
Phosphate $25.00 $35.00 $60.00 $200.00
5'- Amino C6 $25.00 $30.00 $60.00 $250.00
3'- Amino C7 $25.00 $30.00 $60.00 $250.00
Digoxigenin* $175.00 $180.00 $230.00 $750.00
Thiol Modifier C6 S-S $150.00 $180.00 $225.00 $475.00
5'- Thiol $60.00 $75.00 $100.00 $300.00
Internal Modifications
dI N/A $14.00 $17.50 $50.00
dU N/A $14.00 $17.50 $50.00
Abasic N/A $120.00 $160.00 $420.00
2-Aminopurine N/A $160.00 $200.00 $450.00
8-Oxo-dG N/A $200.00 $250.00 $450.00

*Price includes the cost of the required amino group for attachment.

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